DNA ancestry companies generate revenues in the region of $1bn a year, and the company 23andMe is said to have sold 10 million DNA ancestry kits to date. Although evidently popular, the science behind how DNA ancestry tests work is mystifying and difficult for the general public to interpret and understand. In this accessible and engaging book, Sheldon Krimsky, a leading researcher, investigates the methods that different companies use for DNA ancestry testing. He also discusses what the tests are used for, from their application in criminal investigations to discovering missing relatives. With a lack of transparency from companies in sharing their data, absent validation of methods by independent scientists, and currently no agreed-upon standards of accuracy, this book also examines the ethical issues behind genetic genealogy testing, including concerns surrounding data privacy and security. It demystifies the art and science of DNA ancestry testing for the general reader.

Stem cells and the emerging field of regenerative medicine are at the frontiers of modern medicine. These areas of scientific inquiry suggest that in the future, damaged tissue and organs might be repaired through personalized cell therapy as easily as the body repairs itself, revolutionizing the treatment of numerous diseases. Yet the use of stem cells is fraught with ethical and public policy dilemmas that challenge scientists, clinicians, the public health community, and people of good will everywhere. How shall we deal with these amazing biomedical advances, and how can we talk about potential breakthroughs with both moral and scientific intelligence? This book provides an innovative look at these vexing issues through a series of innovative Socratic dialogues that elucidate key scientific and ethical points in an approachable manner. Addressing the cultural and value issues underlying stem cell research while also educating readers about stem cells' biological function and medical applications, Stem Cell Dialogues features fictional characters engaging in compelling inquiry and debate. Participants investigate the scientific, political, and socioethical dimensions of stem cell science using actual language, analysis, and arguments taken from scientific, philosophical, and popular literature. Each dialogue centers on a specific, recognizable topic, such as the policies implemented by the George W. Bush administration restricting the use of embryonic stem cells; the potential role of stem cells in personalized medicine; the ethics of cloning; and the sale of eggs and embryos. Additionally, speakers debate the use of stem cells to treat paralysis, diabetes, stroke effects, macular degeneration, and cancer. Educational, entertaining, and rigorously researched (with 300 references to scientific literature), Stem Cell Dialogues should be included in any effort to help the public understand the science, ethics, and policy concerns of this promising field.

DNA ancestry companies generate revenues in the region of $1bn a year, and the company 23andMe is said to have sold 10 million DNA ancestry kits to date. Although evidently popular, the science behind how DNA ancestry tests work is mystifying and difficult for the general public to interpret and understand. In this accessible and engaging book, Sheldon Krimsky, a leading researcher, investigates the methods that different companies use for DNA ancestry testing. He also discusses what the tests are used for, from their application in criminal investigations to discovering missing relatives. With a lack of transparency from companies in sharing their data, absent validation of methods by independent scientists, and currently no agreed-upon standards of accuracy, this book also examines the ethical issues behind genetic genealogy testing, including concerns surrounding data privacy and security. It demystifies the art and science of DNA ancestry testing for the general reader.

Stem cells and the emerging field of regenerative medicine are at the frontiers of modern medicine. These areas of scientific inquiry suggest that in the future, damaged tissue and organs might be repaired through personalized cell therapy as easily as the body repairs itself, revolutionizing the treatment of numerous diseases. Yet the use of stem cells is fraught with ethical and public policy dilemmas that challenge scientists, clinicians, the public health community, and people of good will everywhere. How shall we deal with these amazing biomedical advances, and how can we talk about potential breakthroughs with both moral and scientific intelligence? This book provides an innovative look at these vexing issues through a series of innovative Socratic dialogues that elucidate key scientific and ethical points in an approachable manner. Addressing the cultural and value issues underlying stem cell research while also educating readers about stem cells' biological function and medical applications, Stem Cell Dialogues features fictional characters engaging in compelling inquiry and debate. Participants investigate the scientific, political, and socioethical dimensions of stem cell science using actual language, analysis, and arguments taken from scientific, philosophical, and popular literature. Each dialogue centers on a specific, recognizable topic, such as the policies implemented by the George W. Bush administration restricting the use of embryonic stem cells; the potential role of stem cells in personalized medicine; the ethics of cloning; and the sale of eggs and embryos. Additionally, speakers debate the use of stem cells to treat paralysis, diabetes, stroke effects, macular degeneration, and cancer. Educational, entertaining, and rigorously researched (with 300 references to scientific literature), Stem Cell Dialogues should be included in any effort to help the public understand the science, ethics, and policy concerns of this promising field.

In "Hormonal Chaos," Sheldon Krimsky traces the emergence of an unorthodox hypothesis that casts new suspicions on a broad range of modern industrial chemicals. At the heart of his story is the "Environmental Endocrine Hypothesis," the assertion that a class of chemicals called "endocrine disruptors" are interfering with the normal functioning of hormones in animals and humans. Krimsky describes how this controversial theory was first elaborated and explores the complex factors that have contributed to its increased legitimacy and continued controversy.

The social science approach to risk has matured over the past two decades, with distinct paradigms developing in disciplines such as anthropology, economics, geography, psychology, and sociology." Social Theories of Risk" traces the intellectual origins and histories of twelve of the established and emerging paradigms from the perspective of their principal proponents. Each contributor examines the underlying assumptions of his or her paradigm, the foundational issue it seeks to address, and likely future directions of research.

Taken together, these essays illustrate that the principal achievement of social sciences has been to broaden the debate about risk beyond the narrow, technical considerations of engineers and the physical and life sciences. The authors conclude that expert knowledge is not value-free, that public perceptions of and attitudes toward risks vary according to a wide range of social, psychological, and cultural variables, and that public opposition to particular risks cannot be assuaged by technical fixes. The essays reveal the circuitous paths that lead people to the study of risk, highlight how these paths have crossed and discuss some of the seminal influences on individuals and the field in general. "Social Theories of Risk" presents a broad, retrospective view of the state of the theory in the social sciences, written by many who have been on the cutting edge of risk research since its early days. The book includes both established and novel perspectives that address the theoretical foundations of the field and reflect what we know about risk as a psychological, social, and cultural phenomenon. The collection of papers not only informs us of the tributary ideas that spawned the social studies of risk, but also how the field has matured. The biographical flavor of the essays provides fascinating reading for established members of the field, and a valuable entree for newcomers. It is an ideal college text for courses in the history of science, environmental policy, and science, technology, and society, as well as the burgeoning array of more specialized courses in risk assessment and management.

National DNA databanks were initially established to catalogue the identities of violent criminals and sex offenders. However, since the mid-1990s, forensic DNA databanks have in some cases expanded to include people merely arrested, regardless of whether they've been charged or convicted of a crime. The public is largely unaware of these changes and the advances that biotechnology and forensic DNA science have made possible. Yet many citizens are beginning to realize that the unfettered collection of DNA profiles might compromise our basic freedoms and rights.

Two leading authors on medical ethics, science policy, and civil liberties take a hard look at how the United States has balanced the use of DNA technology, particularly the use of DNA databanks in criminal justice, with the privacy rights of its citizenry. Krimsky and Simoncelli analyze the constitutional, ethical, and sociopolitical implications of expanded DNA collection in the United States and compare these findings to trends in the United Kingdom, Japan, Australia, Germany, and Italy. They explore many controversial topics, including the legal precedent for taking DNA from juveniles, the search for possible family members of suspects in DNA databases, the launch of "DNA dragnets" among local populations, and the warrantless acquisition by police of so-called abandoned DNA in the search for suspects. Most intriguing, Krimsky and Simoncelli explode the myth that DNA profiling is infallible, which has profound implications for criminal justice.

Do advances in genomic biology create a scientific rationale for long-discredited racial categories? Leading scholars in law, medicine, biology, sociology, history, anthropology, and psychology examine the impact of modern genetics on the concept of race. Contributors trace the interplay between genetics and race in forensic DNA databanks, the biology of intelligence, DNA ancestry markers, and racialized medicine. Each essay explores commonly held and unexamined assumptions and misperceptions about race in science and popular culture.

This collection begins with the historical origins and current uses of the concept of "race" in science. It follows with an analysis of the role of race in DNA databanks and racial disparities in the criminal justice system. Essays then consider the rise of recreational genetics in the form of for-profit testing of genetic ancestry and the introduction of racialized medicine, specifically through an FDA-approved heart drug called BiDil, marketed to African American men. Concluding sections discuss the contradictions between our scientific and cultural understandings of race and the continuing significance of race in educational and criminal justice policy.

The debate over genetically modified organisms: health and safety concerns, environmental impact, and scientific opinions. Since they were introduced to the market in the late 1990s, GMOs (genetically modified organisms, including genetically modified crops), have been subject to a barrage of criticism. Agriculture has welcomed this new technology, but public opposition has been loud and scientific opinion mixed. In GMOs Decoded, Sheldon Krimsky examines the controversies over GMOs-health and safety concerns, environmental issues, the implications for world hunger, and the scientific consensus (or lack of one). He explores the viewpoints of a range of GMO skeptics, from public advocacy groups and nongovernmental organizations to scientists with differing views on risk and environmental impact. Krimsky explains the differences between traditional plant breeding and "molecular breeding" through genetic engineering (GE); describes early GMO products, including the infamous Flavr Savr tomato; and discusses herbicide-, disease-, and insect-resistant GE plants. He considers the different American and European approaches to risk assessment, dueling scientific interpretations of plant genetics, and the controversy over labeling GMO products. He analyzes a key 2016 report from the National Academies of Sciences on GMO health effects and considers the controversy over biofortified rice (Golden Rice)-which some saw as a humanitarian project and others as an exercise in public relations. Do GMO crops hold promise or peril? By offering an accessible review of the risks and benefits of GMO crops, and a guide to the controversies over them, Krimsky helps readers judge for themselves.

National DNA databanks were initially established to catalogue the identities of violent criminals and sex offenders. However, since the mid-1990s, forensic DNA databanks have in some cases expanded to include people merely arrested, regardless of whether they've been charged or convicted of a crime. The public is largely unaware of these changes and the advances that biotechnology and forensic DNA science have made possible. Yet many citizens are beginning to realize that the unfettered collection of DNA profiles might compromise our basic freedoms and rights.

Two leading authors on medical ethics, science policy, and civil liberties take a hard look at how the United States has balanced the use of DNA technology, particularly the use of DNA databanks in criminal justice, with the privacy rights of its citizenry. Krimsky and Simoncelli analyze the constitutional, ethical, and sociopolitical implications of expanded DNA collection in the United States and compare these findings to trends in the United Kingdom, Japan, Australia, Germany, and Italy. They explore many controversial topics, including the legal precedent for taking DNA from juveniles, the search for possible family members of suspects in DNA databases, the launch of "DNA dragnets" among local populations, and the warrantless acquisition by police of so-called abandoned DNA in the search for suspects. Most intriguing, Krimsky and Simoncelli explode the myth that DNA profiling is infallible, which has profound implications for criminal justice.

Do advances in genomic biology create a scientific rationale for long-discredited racial categories? Leading scholars in law, medicine, biology, sociology, history, anthropology, and psychology examine the impact of modern genetics on the concept of race. Contributors trace the interplay between genetics and race in forensic DNA databanks, the biology of intelligence, DNA ancestry markers, and racialized medicine. Each essay explores commonly held and unexamined assumptions and misperceptions about race in science and popular culture.

This collection begins with the historical origins and current uses of the concept of "race" in science. It follows with an analysis of the role of race in DNA databanks and racial disparities in the criminal justice system. Essays then consider the rise of recreational genetics in the form of for-profit testing of genetic ancestry and the introduction of racialized medicine, specifically through an FDA-approved heart drug called BiDil, marketed to African American men. Concluding sections discuss the contradictions between our scientific and cultural understandings of race and the continuing significance of race in educational and criminal justice policy.

Can genes determine which fifty-year-old will succumb to Alzheimer's, which citizen will turn out on voting day, and which child will be marked for a life of crime? Yes, according to the Internet, a few scientific studies, and some in the biotechnology industry who should know better. Sheldon Krimsky and Jeremy Gruber gather a team of genetic experts to argue that treating genes as the holy grail of our physical being is a patently unscientific endeavor. Genetic Explanations urges us to replace our faith in genetic determinism with scientific knowledge about how DNA actually contributes to human development. The concept of the gene has been steadily revised since Watson and Crick discovered the structure of the DNA molecule in 1953. No longer viewed by scientists as the cell's fixed set of master molecules, genes and DNA are seen as a dynamic script that is ad-libbed at each stage of development. Rather than an autonomous predictor of disease, the DNA we inherit interacts continuously with the environment and functions differently as we age. What our parents hand down to us is just the beginning. Emphasizing relatively new understandings of genetic plasticity and epigenetic inheritance, the authors put into a broad developmental context the role genes are known to play in disease, behavior, evolution, and cognition. Rather than dismissing genetic reductionism out of hand, Krimsky and Gruber ask why it persists despite opposing scientific evidence, how it influences attitudes about human behavior, and how it figures in the politics of research funding.

The social science approach to risk has matured over the past two decades, with distinct paradigms developing in disciplines such as anthropology, economics, geography, psychology, and sociology." Social Theories of Risk" traces the intellectual origins and histories of twelve of the established and emerging paradigms from the perspective of their principal proponents. Each contributor examines the underlying assumptions of his or her paradigm, the foundational issue it seeks to address, and likely future directions of research.

Taken together, these essays illustrate that the principal achievement of social sciences has been to broaden the debate about risk beyond the narrow, technical considerations of engineers and the physical and life sciences. The authors conclude that expert knowledge is not value-free, that public perceptions of and attitudes toward risks vary according to a wide range of social, psychological, and cultural variables, and that public opposition to particular risks cannot be assuaged by technical fixes. The essays reveal the circuitous paths that lead people to the study of risk, highlight how these paths have crossed and discuss some of the seminal influences on individuals and the field in general. "Social Theories of Risk" presents a broad, retrospective view of the state of the theory in the social sciences, written by many who have been on the cutting edge of risk research since its early days. The book includes both established and novel perspectives that address the theoretical foundations of the field and reflect what we know about risk as a psychological, social, and cultural phenomenon. The collection of papers not only informs us of the tributary ideas that spawned the social studies of risk, but also how the field has matured. The biographical flavor of the essays provides fascinating reading for established members of the field, and a valuable entree for newcomers. It is an ideal college text for courses in the history of science, environmental policy, and science, technology, and society, as well as the burgeoning array of more specialized courses in risk assessment and management.

Impacts of technological change have historically been assessed only after the passage of a significant period of time. It is then that historians recreate the decisions that were made, sort out the influencing factors, and debate in hindsight the options that were available at the time. Sheldon Krimsky, consistent with the importance of his subject, telescopes this process by providing to contemporary readers a broad overview of the first ten years of the industrial revolution in applied molecular genetics. He discusses the birth and expectations of the biotechnology industry, the response to products of genetic engineering, perspectives on risk assessment from different sectors of the scientific community, and public initiatives to regulate new products. The author explores the social and political discourse on the direction of biotechnology, and offers the most detailed examination to date of the controversy over the environmental release of genetically engineered organisms. Finally, he takes a critical look at the conventional role of technology assessment and suggests an alternative model that fits more closely with the needs of an environmentally sensitive world.

Krimsky's thought-provoking work offers readers a unique opportunity to understand what questions were being asked, what options were available, and what decisions were being made when the industrial application of genetic technologies was still in its infancy. His insider's perspective will interest those working in the fields of biology and social issues; science, technology, and society; and the sociology of science. Challenging, cautioning, and balanced, this book is required reading for all who are seriously concerned with the relationship of emerging technologies to society.

Impacts of technological change have historically been assessed only after the passage of a significant period of time. It is then that historians recreate the decisions that were made, sort out the influencing factors, and debate in hindsight the options that were available at the time. Sheldon Krimsky, consistent with the importance of his subject, telescopes this process by providing to contemporary readers a broad overview of the first ten years of the industrial revolution in applied molecular genetics. He discusses the birth and expectations of the biotechnology industry, the response to products of genetic engineering, perspectives on risk assessment from different sectors of the scientific community, and public initiatives to regulate new products. The author explores the social and political discourse on the direction of biotechnology, and offers the most detailed examination to date of the controversy over the environmental release of genetically engineered organisms. Finally, he takes a critical look at the conventional role of technology assessment and suggests an alternative model that fits more closely with the needs of an environmentally sensitive world.

Krimsky's thought-provoking work offers readers a unique opportunity to understand what questions were being asked, what options were available, and what decisions were being made when the industrial application of genetic technologies was still in its infancy. His insider's perspective will interest those working in the fields of biology and social issues; science, technology, and society; and the sociology of science. Challenging, cautioning, and balanced, this book is required reading for all who are seriously concerned with the relationship of emerging technologies to society.